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Stoffwechselprodukte von Mikroorganismen. 160. Mitteilung . Conocandin, ein fungistatisches Antibiotikum aus Hormococcus conorum (S ACC . et R OUM .) R OBACK
Author(s) -
Müller Johannes M.,
Fuhrer Hermann,
Gruner Johannes,
Voser Walter
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590726
Subject(s) - chemistry , stereochemistry , strain (injury) , medicine
Metabolites from Microorganisms . 160th Communication. Conocandin, a new Fungistatic Antibiotic. From a strain of Hormococcus conorum (S ACC. ET R OUM .) R OBACK A 32′287, conocandin, a novel type C 18 ‐fatty acid with high and specific in vitro fungistatic activity was isolated by means of counter current distribution and silicagel chromatography. The antibiotic is a viscous oil with the molecular formula C 18 H 30 O 3 . It is characterized by IR. and NMR. spectra, ester derivatives and the products of acid rearrangement and ozonolytic degradation. The structure of ( E )‐2‐methylidene‐10‐methyl‐ trans ‐3,4‐epoxy‐9‐hexadecenoic acid ( 1 ) is proposed.