Stoffwechselprodukte von Mikroorganismen. 160. Mitteilung . Conocandin, ein fungistatisches Antibiotikum aus  Hormococcus conorum  (S ACC . et R OUM .) R OBACK | Zendy

Müller Johannes M. | Zendy; Fuhrer Hermann | Zendy; Gruner Johannes | Zendy; Voser Walter | Zendy

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Stoffwechselprodukte von Mikroorganismen. 160. Mitteilung . Conocandin, ein fungistatisches Antibiotikum aus Hormococcus conorum (S ACC . et R OUM .) R OBACK

Author(s) -

Müller Johannes M.,

Fuhrer Hermann,

Gruner Johannes,

Voser Walter

Publication year - 1976

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19760590726

Subject(s) - chemistry , stereochemistry , strain (injury) , medicine

Metabolites from Microorganisms . 160th Communication. Conocandin, a new Fungistatic Antibiotic. From a strain of Hormococcus conorum (S ACC. ET R OUM .) R OBACK A 32′287, conocandin, a novel type C 18 ‐fatty acid with high and specific in vitro fungistatic activity was isolated by means of counter current distribution and silicagel chromatography. The antibiotic is a viscous oil with the molecular formula C 18 H 30 O 3 . It is characterized by IR. and NMR. spectra, ester derivatives and the products of acid rearrangement and ozonolytic degradation. The structure of ( E )‐2‐methylidene‐10‐methyl‐ trans ‐3,4‐epoxy‐9‐hexadecenoic acid ( 1 ) is proposed.

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