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Versuche zu einer neuen Synthese von Cephem‐Verbindungen
Author(s) -
Petrzilka Theodor,
Fehr Charles,
Schmid Gérard
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590612
Subject(s) - chemistry , cephem , intramolecular force , cycloaddition , stereochemistry , pyrolysis , medicinal chemistry , organic chemistry , catalysis , carboxylic acid
Contributions for a new synthesis of Cephem compounds. Compounds 10 and 12 of type 2 were synthesized by pyrolysis of phenoxy‐urethanes 9 and 11 . The unsaturated side chain was synthesized by Michael ‐addition of 7 to propiolic acid. Intramolecular [2 + 2]‐Cycloaddition attempts on compounds 10 and 12 were not successful.