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Stereospezifität der neuroleptischen Wirkung und Chiralität von (+)‐3‐{2‐[4‐(8‐Fluor‐2‐methyl‐10,11‐dihydrodibenzo[ b,f ]thiepin‐10‐yl)‐1‐piperazinyl]‐äthyl}‐2‐oxazolidinon (16). 4. Mitteilung über tricyclische Antidepressiva und Neuroleptica
Author(s) -
Aschwanden Werner,
Kyburz Emilio,
Schönholzer Peter
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590428
Subject(s) - chemistry , stereochemistry , enantiomer , stereospecificity , medicinal chemistry , organic chemistry , catalysis
Stereospecifity of the neuroleptic activity and chirality of (+)‐3‐{2‐[4‐(8‐fluoro‐2‐methyl‐10, 11‐dihydrodibenzo[ b,f ]thiepin‐10‐yl)‐1‐piperazinyl]ethyl}‐2‐oxazolidinone (16). The synthesis and stereospecific neuroleptic action in animals of the (+)‐enantiomer of 3‐{2‐[4‐(8‐fluoro‐2‐methyl‐10,11‐dihydrodibenzo [ b,f ]thiepin‐10‐yl)‐1‐piperazinyl]ethyl}‐2‐oxazolidinone ( 16 ) are briefly described. The (10S)‐configuration of this compound was determined by X‐ray diffraction.