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Neue Verfahren zur Herstellung von 21‐Fluorsteroiden. Über Steroide. 232. Mitteilung
Author(s) -
Wieland Peter
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590408
Subject(s) - chemistry , medicinal chemistry , steroid , fluoride , diazo , organic chemistry , inorganic chemistry , hormone , biochemistry
New methods for the preparation of 21‐fluoro‐steroids. 21‐Fluoro‐20‐oxosteroids are obtained either by reacting a 21‐diazo‐20‐oxo‐steroid with hydrofluoric acid or by subjecting a 21‐mesyloxy‐20‐oxo‐steroid to reduction with the radical anion derived from lithium and biphenyl, followed by treatment of the resulting enolate with perchloryl fluoride.