Premium
15 N Labelling: Potassium azide, tetrazoles and imidazoles
Author(s) -
Wentrup Curt,
Thétaz Célestin
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590130
Subject(s) - chemistry , labelling , azide , yield (engineering) , potassium , hydrolysis , ring (chemistry) , pyrolysis , sodium azide , medicinal chemistry , organic chemistry , radiochemistry , metallurgy , biochemistry , materials science
A simplified high‐yield preparation of end‐labelled potassium azide from K 15 NO 3 is described. Treatment of 4‐chloropyrimidines with K 15 NN 2 and subsequent gas‐phase pyrolysis gives ring‐labelled 1‐cyanoimidazoles in 80–100% yields. The cyano‐groups in the latter are easily removed by hydrolysis.