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Pseurotin, a New Metabolite of Pseudeurotium ovalis S TOLK Having an Unusual Hetero‐Spirocyclic System. (Preliminary Communication)
Author(s) -
Bloch Peter,
Tamm Christoph,
Bollinger Pietro,
Petcher Trevor J.,
Weber Hans Peter
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590114
Subject(s) - chemistry , metabolite , stereochemistry , derivative (finance) , absolute configuration , biochemistry , financial economics , economics
The structure and absolute configuration of pseurotin ( 1 ), a new metabolite, isolated from culture filtrates of Pseudeurotium ovalis S TOLK ( Ascomycetes ), has been shown to be 2‐[1′(S), 2′ (S)‐dihydroxhex‐3′‐ene‐yl]‐3‐methyl‐8(S)‐methoxy‐8‐benzoyl‐9(R)‐hydroxy‐(5S)‐1‐oxa‐7‐aza‐spiro[4.4]non‐2‐ene‐4, 6‐dione ( 1 ), by spectral data and chemical transformations, and by X‐ray analysis of its dibromo derivative 2 [1].