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Fluororganische Synthesen V Darstellung und Abwandlung von Chlorfluorcyclopropanen ‐ Ein gezielter Zugang zu Fluorallylalkoholen
Author(s) -
Schlosser Manfred,
Van Chau Le
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580844
Subject(s) - chemistry , saponification , yield (engineering) , olefin fiber , ring (chemistry) , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy
Fluoroorganic Syntheses V. Preparation and Transformation of Chlorofluorocyclopropanes. – A Selective Approach to Fluoroallylic Alcohols Chlorofluorocarbene addition to unsaturated compounds is particularly convenient and efficient in a two‐phase system. This method works satisfactorily even if the olefin carries base‐sensitive substituents. The resultant chlorofluorocyclopropanes can be ring‐opened by silver‐salt assisted acetolysis affording 2‐fluorallylacetates, which yield 2‐fluorallylic alcohols upon saponification.