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Über einen neuen Zugang zu Imidazolen, sowie deren Verwendung zur Synthese von Purinen und 4,6‐Dihydro‐1,2‐dimethyl‐8‐phenylimidazo[4,5‐ e ]‐1,4‐diazepin‐5(1 H )‐on
Author(s) -
Edenhofer Albrecht
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580732
Subject(s) - chemistry , imidazole , purine metabolism , combinatorial chemistry , stereochemistry , organic chemistry , enzyme
A novel route to imidazoles and their use for the synthesis of purines and 4,6‐dihydro‐1,2‐dimethyl‐8‐phenylimidazo[4,5‐ e ]‐1,4‐diazepin‐5(1H)‐on. Recently it has been shown [2] that pyrimidines are available from Thorpe‐Ziegler cyclization of the appropriate dinitriles. As an extension of this work, a novel route to imidazoles has been developed. It has been demonstrated that these imidazole derivatives are valuable intermediates for the synthesis of purines by application of standard procedures. The use of these imidazoles has enabled the preparation of some derivatives not accessible by other methods.