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Synthesis of Heparin Saccharides IV. Synthesis of disaccharides possessing the structure of a repeating unit of heparin
Author(s) -
Wyss Pierre C.,
Kiss Joseph,
Arnold Wolf
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580641
Subject(s) - chemistry , glucosamine , heparin , stereochemistry , d glucosamine , disaccharide , glycosaminoglycan , organic chemistry , biochemistry
The synthesis of disaccharides possessing the structure of a repeating unit of heparin is reported. 2‐Acetamido‐2‐deoxy‐4‐O‐(methyl α‐D‐glucopyranosyluronate)‐D‐glucopyranose ( 1 ) and 2‐[1‐(benzyloxy)formamido]‐2‐deoxy‐4‐O‐(methyl α‐D‐glucopyranosyluronate)‐D‐glucopyranose ( 2 ) have been prepared by two routes, (a) from D‐glucose and D‐glucosamine, and (b) from D‐glucuronolactone and D‐glucosamine.