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Selektive Funktionalisierung von Wortmannin mit Hilfe einer Furanring‐Maskierung
Author(s) -
Haefliger Walter,
Kis Zoltan,
Hauser Daniel
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580616
Subject(s) - chemistry , wortmannin , transformation (genetics) , ring (chemistry) , reagent , nucleophile , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , apoptosis , pi3k/akt/mtor pathway , gene
Wortmannin ( 1 ) and its 11‐desacetoxy derivative 2 are highly susceptible to nucleophiles, which limits the possibilities of transformation. Masking the furan ring by a new method allowed selective transformations with various reagents.