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Beitrag zur Partialsynthese 18‐oxygenierter Cortexone I. Synthese von 18‐Hydroxy‐cortexon Über Steroide, 230. Mitteilung
Author(s) -
Biollaz Michel,
Kalvoda Jaroslav,
Schmidlin Julius
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580518
Subject(s) - chemistry , enol , stereochemistry , sequence (biology) , combinatorial chemistry , organic chemistry , catalysis , biochemistry
Two improved procedures for the synthesis of 18‐hydroxycortexone and derivatives thereof are presented. One approach involved the development of an efficient method for preparing cyclic 20‐enol ethers as key intermediates for the oxygenation at position 21. In an alternative sequence, starting from a 21‐hydroxypregnene compound, 18‐functionalization has been achieved as the final step by hypoiodite reaction .