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Steroids. Part I. Selective Hydrogenation of Ergosterol and its Acetate
Author(s) -
Tadros Wadie,
Boulos Adel Louis
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580303
Subject(s) - chemistry , acetaldehyde , yield (engineering) , ergosterol , benzaldehyde , organic chemistry , raney nickel , propiophenone , paraformaldehyde , ethyl acetate , ethanol , catalysis , ketone , biochemistry , materials science , metallurgy
Selective hydrogenation of ergosterol or its acetate in solution in different solvents over Raney nickel to give 5α‐ergosta‐7,22‐dien‐3β‐ol or its acetate can be controlled by the addition of paraformaldehyde, acetaldehyde, benzaldehyde, 4‐dimethylaminobenzaldehyde, and dimethylaniline, the latter 2 giving the best yield. When using pure solvents 5α‐ergost‐7‐en‐3β‐ol or its acetate can be obtained in almost quantitative yield.