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Eine chiral ökonomische Totalsynthese von natürlichen und unnatürlichen Prostaglandinen
Author(s) -
Fischli Albert,
Klaus Michael,
Mayer Hans,
Schönholzer Peter,
Rüegg Rudolf
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580228
Subject(s) - chemistry , enantiomer , moiety , optically active , stereochemistry , combinatorial chemistry , sequence (biology) , organic chemistry , biochemistry
Using a meso ‐compound which is asymmetrically substituted with a chiral moiety as an intermediate, prostaglandins have been synthesized. Since the undesired enantiomer is readily recycled, this approach leads to a synthesis with high chiral efficiency. In addition it is possible to prepare both enantiomeric configurations of prostaglandins by simply altering the sequence of reactions. This concept should be generally useful in the synthesis of optically active molecules.