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Improved Synthesis of O‐Phosphohomoserine
Author(s) -
Schnyder Jörg,
Rottenberg Max
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580221
Subject(s) - chemistry , hydrogenolysis , yield (engineering) , hydrolysis , pyridine , catalysis , chloride , medicinal chemistry , organic chemistry , materials science , metallurgy
O‐Phosphohomoserine (PHS) was prepared in an overall yield of 49% by treatment of N‐benzyloxycarbonyl‐homoserine p‐nitrobenzyl ester with diphenylphosphoryl chloride in pyridine, followed by catalytic hydrogenolysis. Both L ‐ and D , L ‐phosphohomoserine were found to be 100% hydrolyzed by alcaline phosphatase from E. coli.