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Biosynthese der Verrucarine und Roridine. Teil 3. Der Einbau von (3 R )‐[5‐ 14 C]‐, [2‐ 14 C]‐ und an C(2) stereospezifisch tritiiertem Mevalonat in Verrucarol Verrucarine und Roridine, 29. Mitteilung
Author(s) -
Müller Beat,
Achini Roland,
Tamm Christoph
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580216
Subject(s) - chemistry , stereochemistry , hydroxylation , enzyme , biochemistry
Separate experiments, involving incorporation of either (3R)‐[5‐ 14 C]‐mevalonate or each enantiomer of [2‐ 3 H]‐mevalonate into verrucartin A and roridin A, indicate that hydroxylation at C(4) of the tricothecane skeleton, to yield verrucarol (4), proceeds with an overall retention of configuration; they confirm that C(8) and not C(10) is derived specifically from C(2) or mevalonate.