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Synthetische Juvenilhormone 2. Mitteilung. p ‐Substituierte 2‐Methyl‐3‐phenyl‐propen(1)‐carbonsäurederivate
Author(s) -
Franke Albrecht,
Mattern Günter,
Traber Walter
Publication year - 1975
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19750580134
Subject(s) - chemistry , decarboxylation , steric effects , wittig reaction , medicinal chemistry , carboxylic acid , stereochemistry , organic chemistry , catalysis
In the second communication the synthesis of para‐substituted 2‐methyl‐3‐phenylpropen(1)‐carboxylic acid derivatives is described: Phenylacetone compounds are formed by decarboxylation of a glycidicester; these react according to the Wadsworth ‐ Emmons ( Wittig ‐ Horner )‐reaction with the corresponding phosphonates to the title compounds. NMR. data show the formation of the steric isomers of 3‐Phenyl‐2‐methyl‐propen‐1‐ and 3‐Phenyl‐2‐methylpropen‐2‐carboxylic acid derivatives.