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Asymmetrische homogene Hydrierung am Beispiel der Hydrierung eines Thiophenderivates
Author(s) -
Stoll André P.,
Süess Rudolf
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570821
Subject(s) - chemistry , yield (engineering) , acrylic acid , catalysis , medicinal chemistry , organic chemistry , copolymer , polymer , materials science , metallurgy
(+)‐2‐(4‐Methoxy‐5‐phenyl‐3‐thienyl)propionic acid ( 1 ) was obtained by asymmetric hydrogenation of 2‐(4‐methoxy‐5‐phenyl‐3‐thienyl)acrylic acid ( 11 ) in 97% yield and with an optical purity of 88% using Kagan 's catalyst. The racemic acid 1 was also prepared by an independent route and resolved by classical techniques.