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Metabolites of Microorganisms. 144th communication . The Crystal and Molecular Structure of 3‐Hydroxy‐4‐methylproline
Author(s) -
Koyama Gunji
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570819
Subject(s) - chemistry , orthorhombic crystal system , zwitterion , hydrolysate , hydrogen bond , crystal structure , molecule , stereochemistry , absolute configuration , crystallography , organic chemistry , hydrolysis
A new amino acid isolated from the acid hydrolysate of the antibiotic Echinocandin B is shown by X‐ray analysis to be 2,3– trans ‐3,4‐ cis ‐3‐hydroxy‐4‐methylproline. The crystals are orthorhombic, a = 5.633 Å, b = 8.760 Å, c = 14.314 Å, Z = 4, space group P2 1 2 1 2 1 . The structure was determined by direct methods and refined by least‐squares analysis to a final R value of 0.032 for 532 reflections. The molecule exists as a zwitterion forming one OH…O and two NH…O hydrogen bonds.
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