Premium
Neue β‐Lactam‐Antibiotika. Über die Darstellung und Decarbonylierung von 3‐Formylcephem‐Verbindungen. Modifikationen von Antibiotica, 12. Mitteilung [1]
Author(s) -
Peter Heinrich,
Bickel Hans
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570715
Subject(s) - chemistry , cephem , decarbonylation , lactam , medicinal chemistry , tris , acyl chloride , rhodium , triphenylphosphine , carboxylic acid , stereochemistry , chloride , organic chemistry , catalysis , biochemistry
Benzhydrylic esters of 3‐unsubstituted cephem‐4‐carboxylic acids of types 9 and 10 ( Scheme 2 ) are prepared by decarbonylation of esters of 3‐formylcephem compounds of type 2 with tris‐triphenylphosphine‐rhodium chloride. The preparation of the starting materials 2 and 5 , as well as of the nucleus 13 is described.