Neue β‐Lactam‐Antibiotika. Über die Darstellung und Decarbonylierung von 3‐Formylcephem‐Verbindungen. Modifikationen von Antibiotica, 12. Mitteilung [1] | Zendy

Peter Heinrich | Zendy; Bickel Hans | Zendy

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Neue β‐Lactam‐Antibiotika. Über die Darstellung und Decarbonylierung von 3‐Formylcephem‐Verbindungen. Modifikationen von Antibiotica, 12. Mitteilung [1]

Author(s) -

Peter Heinrich,

Bickel Hans

Publication year - 1974

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19740570715

Subject(s) - chemistry , cephem , decarbonylation , lactam , medicinal chemistry , tris , acyl chloride , rhodium , triphenylphosphine , carboxylic acid , stereochemistry , chloride , organic chemistry , catalysis , biochemistry

Benzhydrylic esters of 3‐unsubstituted cephem‐4‐carboxylic acids of types 9 and 10 ( Scheme 2 ) are prepared by decarbonylation of esters of 3‐formylcephem compounds of type 2 with tris‐triphenylphosphine‐rhodium chloride. The preparation of the starting materials 2 and 5 , as well as of the nucleus 13 is described.

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