Neue Derivate der 7‐Amino‐cephalosporansäure. Über die Substitution der Acetoxygruppe durch aromatische Reste . Modifikationen von Antibiotica, 11. Mitteilung [1] | Zendy

Peter Heinrich | Zendy; Rodriguez Hermann | Zendy; Müller Beat | Zendy; Sibral Walter | Zendy; Bickel Hans | Zendy

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Neue Derivate der 7‐Amino‐cephalosporansäure. Über die Substitution der Acetoxygruppe durch aromatische Reste . Modifikationen von Antibiotica, 11. Mitteilung [1]

Author(s) -

Peter Heinrich,

Rodriguez Hermann,

Müller Beat,

Sibral Walter,

Bickel Hans

Publication year - 1974

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19740570714

Subject(s) - chemistry , trifluoroacetic acid , nucleophile , medicinal chemistry , stereochemistry , organic chemistry , catalysis

7‐Phenylacetamido‐3‐trifluoroacetoxymethyl‐ceph‐2‐em‐4‐carboxlic acid ( 7 ), which is easily produced from the iso ‐cephalosporanic acid derivatives 4 or 6 by treatment with trifluoroacetic acid, reacts smoothly with ‘C‐nucleophiles’ to give derivatives of type 5 ( Schema 1 and 2 ). Compounds 5 are converted into microbiologically active cephalosporins of type 8 (Table) by previously described methods.

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