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Biosynthese der Cytochalasane. Teil II Die Grundbausteine von Cytochalasin D
Author(s) -
Lebet ClaudeRené,
Tamm Christoph
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570629
Subject(s) - chemistry , cytochalasin , methionine , stereochemistry , cytochalasin b , biochemistry , amino acid , in vitro , cytoskeleton , cell
A number of potential 14 C‐ and 3 H‐labelled precursors were fed to growing cultures of Zygosporium masonii after the rate of formation of cytochalasin D had been measured. By chemical degradation of [ 14 C]‐ and [ 3 H, 14 C]‐cytochalasin D the distribution of the radioactivity originating from incorporated [4′‐3H, U‐ 14 C]‐ L ‐phenylalanine and [CH 3 ‐ 14 C]‐ L ‐methionine was determinated. The results demonstrate that the building blocks of cytochalasin D are 1 unit of pheylalanine, 3 units of methionine and acetate units.
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