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Über Pterinchemie. 49. Mitteilung. Eine neue Synthese von 5‐Formyl‐6, 7‐dimethyl‐5,6,7,8‐tetrahydropterin und 5,6,7‐Trimethyl‐5,6,7,8‐tetrahydropterin
Author(s) -
Bieri Jost H.,
Viscontini Max
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570618
Subject(s) - chemistry , formylation , medicinal chemistry , stereochemistry , organic chemistry , catalysis
Starting with 5‐formyl‐6,7‐dimethyl‐5,6,7,8‐tetrahydropterine (II), a new synthesis of 5,6,7‐trimethyl‐5,6,7,8‐tetrahydropterine (III) is described. Thereby the chemical behaviour of the 5‐formyl group in II is investigated, in order to enable the unequivocal differentiation between formylation at position 5 and at position 10 in folic and tetrahydrofolic acid derivatives. 13 C‐NMR. spectra of II and III are discussed.