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Selektive Synthesen mit Organometallen I. Konfigurativ einheitliche Folgeprodukte aus Alkenylkalium‐Zwischenstufen
Author(s) -
Schlosser Manfred,
Hartmann Jürgen,
David Victor
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570611
Subject(s) - chemistry , isomerization , stereoselectivity , alkyl , double bond , stereochemistry , medicinal chemistry , catalysis , polymer chemistry , organic chemistry
Methyl groups in positions adjacent to an olefinic double bond can be metalated without cis/trans isomerisation. On the other hand configurational changes can be brought about via metalotropy; under equilibrium conditions the Z isomers (metal cis to an alkyl in β position) predominate overwhelmingly. This behaviour opens new stereoselective routes of high preparative utility.
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