Premium
5‐(1‐Alkenyl)‐1, 3, 4‐oxadiazol‐2(3 H )‐one
Author(s) -
Rüfenacht Kurt
Publication year - 1974
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19740570223
Subject(s) - chemistry , phosgene , ring (chemistry) , bromine , hydrazine (antidepressant) , closure (psychology) , medicinal chemistry , organic chemistry , stereochemistry , chromatography , economics , market economy
3‐(2‐alkenoyl)‐thiocarbazic acid O‐methyl esters 1 are desulfurated by bromine and the unknown intermediates are transformed by alkali to 5‐(1‐alkenyl)‐1, 3, 4‐oxadiazol‐2(3 H )‐ones ( 2 ). This type of oxadiazolone substitution is not realizable by the common ring closure of hydrazides with phosgene due to pyrazolidinone ring closure of unsaturated acids with hydrazine.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom