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Über Pterinchemie. 44. Mitteilung. Eine eindeutige Synthese isomerenfreier Folsäure
Author(s) -
Bieri Jost H.,
Viscontini Max
Publication year - 1973
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19730560829
Subject(s) - chemistry , folic acid , yield (engineering) , hydrolysis , medicinal chemistry , stereochemistry , organic chemistry , medicine , materials science , metallurgy
A new, simplified and unequivocal synthesis of folic acid free of isomers is described. A melt of N(2′)‐acetyl‐6‐formylpterine and dimethyl‐N‐( p ‐aminobenzoyl)‐L‐glutamate was quantitatively converted to 6‐azomethin‐pterine‐ester IV. NaBH 4 ‐reduction followed by basic hydrolysis of acetyl and ester groups gives pure folic acid in good yield.