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Zur Kontrolle von Solid‐phase Peptidsynthesen durch Eluat‐Chloridbestimmung
Author(s) -
Fankhauser Peter,
Fries Peter,
Brenner Max
Publication year - 1973
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19730560734
Subject(s) - chemistry , methylene , chloride , chloroform , phase (matter) , combinatorial chemistry , chromatography , organic chemistry
The origin of chloride ion in chloroform and methylene chloride solutions of tertiary amines is studied. The applicability of such solutions in the analytical control of solid phase peptide synthesis must be seriously questioned. An alternative procedure, amenable to automation, is suggested.