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Demethylierungen am Mesembrin
Author(s) -
Pfäffli P.,
Hauth H.
Publication year - 1973
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19730560126
Subject(s) - chemistry , demethylation , alkaloid , ring (chemistry) , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , gene expression , dna methylation , gene
The N‐methyl group of mesembrine ( 1 ) was split off via reaction of chloroformic acid p ‐nitrophenyl ester on the keto‐protected alkaloid. O‐Demethylation of 1 with borontribromide produced simultaneous ring closure between the carbonyl function and the aromatic part of the molecule.