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The Use of Intermediates with Preformed Disulfide Bridge for the Synthesis of Oxytocin and Deamino‐oxytocin
Author(s) -
Mühlemann M.,
Titov M. I.,
Schwyzer R.,
Rudinger J.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550817
Subject(s) - chemistry , oxytocin , disulfide bond , amide , glycine , stereochemistry , bridge (graph theory) , derivative (finance) , amino acid , combinatorial chemistry , organic chemistry , biochemistry , medicine , financial economics , economics
The disulfide‐bridged hexapeptides 6a and 6b have been prepared from benzyl‐protected intermediates. Coupling of 6a and 6b with prolyl‐leucyl‐glycine amide afforded deamino‐oxytocin ( 7a ) and the protected oxytocin derivative 7b , respectively; the latter was converted to oxytocin ( 7c ) by removal of the Boc protecting group.