The Use of Intermediates with Preformed Disulfide Bridge for the Synthesis of Oxytocin and Deamino‐oxytocin | Zendy

Mühlemann M. | Zendy; Titov M. I. | Zendy; Schwyzer R. | Zendy; Rudinger J. | Zendy

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The Use of Intermediates with Preformed Disulfide Bridge for the Synthesis of Oxytocin and Deamino‐oxytocin

Author(s) -

Mühlemann M.,

Titov M. I.,

Schwyzer R.,

Rudinger J.

Publication year - 1972

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19720550817

Subject(s) - chemistry , oxytocin , disulfide bond , amide , glycine , stereochemistry , bridge (graph theory) , derivative (finance) , amino acid , combinatorial chemistry , organic chemistry , biochemistry , medicine , financial economics , economics

The disulfide‐bridged hexapeptides 6a and 6b have been prepared from benzyl‐protected intermediates. Coupling of 6a and 6b with prolyl‐leucyl‐glycine amide afforded deamino‐oxytocin ( 7a ) and the protected oxytocin derivative 7b , respectively; the latter was converted to oxytocin ( 7c ) by removal of the Boc protecting group.

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