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Dérivés C‐glycosyliques X . C‐Nucléosides oxadiazoliques inversés. Communication préliminaire
Author(s) -
Tronchet J. M. J.,
Moskalyk R. E.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550812
Subject(s) - chemistry , stereochemistry , nucleoside , medicinal chemistry
The synthesis of «reversed» 1, 3, 4‐oxadiazolyl C‐nucleosides by treatment of alduronic chlorides with N‐benzoylamino‐triphenylphosphinimine or by oxidation of aldehydo dialdose benzoylphenylhydrazones is described. One of these compounds is the first example of an «reversed» C‐amino‐nucleoside having a β‐heteroaryl‐ethylamino grouping, a structural unit whose introduction into a sugar molecule is interesting from a pharmacological standpoint.