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Über atropisomere Biphenyl‐Derivate mit einer Pseudoasymmetrieachse
Author(s) -
Helmchen G.,
Prelog V.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550737
Subject(s) - chemistry , biphenyl , diastereomer , absolute configuration , stereochemistry , nitro , medicinal chemistry , organic chemistry , alkyl
Diastereomeric biphenyl derivatives VIIIa and b have been prepared as first examples of compounds with an axis of pseudoasymmetry. Compound VIIIa was prepared by an unambiguous synthesis from (+)‐V. The absolute configuration of the latter was determined by correlation with (+)‐( R )‐2‐amino‐2′,6‐dimethyl‐6′‐nitro‐biphenyl (XII) and hence the configuration of VIIIa (and therefore also of VIII b) was established.