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Neue β‐Lactam‐Antibiotika. Über die Darstellung der 8‐β‐Phenylacetamido‐homoceph‐4‐em‐5‐carbonsäure (1). Modifikationen von Antibiotika, 7. Mitteilung
Author(s) -
Scartazzini R.,
Gosteli J.,
Bickel H.,
Woodward R. B.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550734
Subject(s) - chemistry , acrolein , thiazolidine , lactam , stereochemistry , organic chemistry , catalysis
The thiazolidine β‐lactam 3 adds acrolein in a Michael type reaction. The resulting 'carbinolamide 4 is converted to 8‐β‐phenylacetamido‐homoceph‐4‐em‐5‐carboxylic acid ( 1 ) by previously described methods.