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The Effect of Solvent Variation on Nucleophilic Substitution Rates of Methyl Tosylate
Author(s) -
Müller Paul,
Siegfried Bernard
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550714
Subject(s) - chemistry , dilution , bromide , solvent , activity coefficient , nucleophilic substitution , medicinal chemistry , solvent effects , reaction rate constant , nucleophile , computational chemistry , organic chemistry , thermodynamics , kinetics , aqueous solution , physics , quantum mechanics , catalysis
Rates of the reactions between bromide ion and methyl tosylate have been determined in 12 solvents and extrapolated to infinite dilution. The data are correlated with Parker 's solvent activity coefficients by means of an empirical equation of the type: logk s – logk 0 = A log 0 γ s i+ B with the constants A = 0.788 and B = 0,108 and a correlation coefficient of 0.983.