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Die Synthese von asymmetrisch substituierten o‐Hydroxyphenyl‐ s ‐triazinen
Author(s) -
Brunetti H.,
Lüthi C. E.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550520
Subject(s) - chemistry , resorcinol , substituent , medicinal chemistry , stereochemistry , organic chemistry
Mono‐ and bis‐(2‐hydroxyphenyl)‐ s ‐triazines 4 , 14 , 18 , 22 , 28 , 29 can be prepared by (a) reaction of salicylic acid esters 2 with amidines 3 ; (b) reaction of 4 H ‐1, 3‐benzoxazin‐4‐ones 10 with amidines 3 ; and (c) Friedel‐Crafts ‐reaction of chloro‐ s ‐triazines 26 , 27 with resorcinol 24 . In case (b) the path of reaction is determined by the character of substituent R 4 in 10 . Scope and limitations of these reactions and accessibility of starting materials are discussed.