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Myrochromanol und Myrochromanon, zwei weitere Metaboliten von Myrothecium roridum Tode ex Fr. Verrucarine und Roridine, 25. Mitt.
Author(s) -
Tamm Ch.,
Böhner B.,
Zürcher W.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550222
Subject(s) - chemistry , stereochemistry , propenyl , medicinal chemistry
From cultures of Myrothecium roridum Tode ex Fr . myrochromanol ( 1 ) and myrochromanone ( 3 ), two new substituted chromanes, have been isolated. Their structures as 2 ‐(1‐propenyl)‐4‐hydroxy‐6‐methyl‐chromane and 2 ‐(1‐propenyl)‐4‐oxo‐6‐methyl‐chromane respectively, have been determined using spectroscopic techniques and by degradation to 2 ‐hydroxy‐5‐methylbenzoic acid ( 6 ). The stereochemistry of 1 and 2 is deduced by NMR., CD. and by partial resolution ( Horeau method).