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Eine neue Synthese des Antibioticums Pyrrolnitrin
Author(s) -
Gosteli J.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550216
Subject(s) - chemistry , toluene , stereochemistry , sequence (biology) , nitro , medicinal chemistry , organic chemistry , biochemistry , alkyl
Abstract 2‐Methyl‐4‐(2‐nitro‐3‐chloro‐phenyl)‐5‐ethoxycarbonyl‐pyrrole is prepared in six steps from 2‐amino‐3‐chloro‐toluene. As the former compound has been converted into pyrrolnitrin by Nakano et al. [4], the reaction sequence described here constitutes a novel synthesis of the antibiotic.