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Neue β‐Lactam‐Antibiotika. Über die Darstellung von N‐Acylderivaten der 7‐Amino‐ceph‐3‐em‐4‐carbonsäure. Modifikationen von Antibiotica, 6. Mitteilung [1]
Author(s) -
Scartazzini R.,
Bickel H.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550212
Subject(s) - chemistry , acylation , lactam , alkylation , zinc , carboxylic acid , acetic acid , stereochemistry , organic chemistry , catalysis
Oxydation of 2 with iodine followed by acylation leads to β‐lactamdisulfides of type 3 . Compounds 3 can be transformed into alcohols 4 by reductive alkylation with ethylenoxide and zinc/acetic acid. Compounds 4 are used as starting materials for the synthesis of N‐acylderivatives 12 of 7‐amino‐ceph‐3‐em‐4‐carboxylic acid ( D ).