Premium
Neue β‐Lactam‐Antibiotika. Über die Darstellung der «7‐Aminocephalocillansäure». Modifikationen von Antibiotika, 4. Mitteilung [1]
Author(s) -
Scartazzini R.,
Peter H.,
Bickel H.,
Heusler K.,
Woodward R. B.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550210
Subject(s) - chemistry , lactam , phosphorane , antibiotics , stereochemistry , biochemistry
‘7‐aminocephalocillanic acid’ 1 , an intermediate for the preparation of new β‐lactam antibiotics was prepared by transforming the β‐lactam carbinol 2a to the phosphorane 9a through several steps. Oxydation of 9a with DMSO/Ac 2 O led directly to the cyclized ester 11a , which has been converted into 1 by known methods.