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Stoffwechselprodukte von Mikroorganismen. 98. Mitteilung. Phosphinothricin und Phosphinothricyl‐Alanyl‐Alanin
Author(s) -
Bayer E.,
Gugel K. H.,
Hägele K.,
Hagenmaier H.,
Jessipow S.,
König W. A.,
Zähner H.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550126
Subject(s) - chemistry , tripeptide , stereochemistry , glutamine , botrytis cinerea , amino acid , biochemistry , botany , biology
Abstract From cultures of Streptomyces viridochromogenes a new antibiotic, phosphinothricylalanyl‐alanine, has been isolated. The new amino acid phosphinothricin is 2‐amino‐4‐methyl‐phosphino‐butyric acid, its structure is confirmed by synthesis. The tripeptide is highly active against Gram ‐positive and Gram ‐negative bacteria and against the fungus Botrytis cinerea . Phosphinothricin is an active glutamine synthetase inhibitor.