Synthèse du méthanesulfonate de (pyrimidyl‐2)‐1‐(méthylène)‐(dioxy‐3, 4‐benzyl)‐4‐pipérazinium (Piribedil)  marqué au  14 C | Zendy

Lintermans J. | Zendy; Benakis A. | Zendy; Herbert M. | Zendy; Pichat L. | Zendy

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Synthèse du méthanesulfonate de (pyrimidyl‐2)‐1‐(méthylène)‐(dioxy‐3, 4‐benzyl)‐4‐pipérazinium (Piribedil) marqué au 14 C

Author(s) -

Lintermans J.,

Benakis A.,

Herbert M.,

Pichat L.

Publication year - 1971

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19710540625

Subject(s) - chemistry , piperazine , medicinal chemistry , labelling , stereochemistry , mass spectrum , organic chemistry , ion , biochemistry

The synthesis of crystalline 1‐(2‐pyrimidyl)‐4‐(3, 4‐methylenedioxybenzyl)‐piperazin methanesulfonate (ET 495) labelled with 14 C fixed on the piperazine nitrogen N(4) has been realized in five steps from barium carbonate 14 C; Specific activity of the final product: 32,8 mCi/mmol (110 m̈Ci/mg); radiochemical purity: around 99%. The mass spectrum of the labelled compound is in agreement with the chemical structure and the labelling position expected.

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