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Synthèse du méthanesulfonate de (pyrimidyl‐2)‐1‐(méthylène)‐(dioxy‐3, 4‐benzyl)‐4‐pipérazinium (Piribedil) marqué au 14 C
Author(s) -
Lintermans J.,
Benakis A.,
Herbert M.,
Pichat L.
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540625
Subject(s) - chemistry , piperazine , medicinal chemistry , labelling , stereochemistry , mass spectrum , organic chemistry , ion , biochemistry
The synthesis of crystalline 1‐(2‐pyrimidyl)‐4‐(3, 4‐methylenedioxybenzyl)‐piperazin methanesulfonate (ET 495) labelled with 14 C fixed on the piperazine nitrogen N(4) has been realized in five steps from barium carbonate 14 C; Specific activity of the final product: 32,8 mCi/mmol (110 m̈Ci/mg); radiochemical purity: around 99%. The mass spectrum of the labelled compound is in agreement with the chemical structure and the labelling position expected.