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Über die Bedeutung des Histidins im «Thyrotropin‐releasing» Hormon (TRH)
Author(s) -
Gillessen D.,
Studer R. O.,
Piva F.,
Steiner H.
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540513
Subject(s) - chemistry , thyrotropin releasing hormone , histidine , alanine , arginine , residue (chemistry) , bioassay , stereochemistry , biological activity , lysine , hormone , amino acid , endocrinology , medicine , biochemistry , in vitro , biology , genetics
The syntheses and biological activities of 4 analogues of the thyrotropin‐releasing hormone (TRH) are described. In these analogues the histidine residue has been replaced by L ‐lysine, L ‐α,γ‐diaminobutyric acid, β‐(3‐pyrazolyl)‐ L ‐alanine, and L‐arginine. All analogues exhibited the characteristic biological responses of TRH. For the β‐(3‐pyrazolyl)‐ L ‐alanine analogue as well as for TRH the bioassays suggest an induction of a strong and rapid resynthesis of thyrotropin (TSH) in higher (μg) concentrations.