Über die Bedeutung des Histidins im «Thyrotropin‐releasing» Hormon (TRH) | Zendy

Gillessen D. | Zendy; Studer R. O. | Zendy; Piva F. | Zendy; Steiner H. | Zendy

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Über die Bedeutung des Histidins im «Thyrotropin‐releasing» Hormon (TRH)

Author(s) -

Gillessen D.,

Studer R. O.,

Piva F.,

Steiner H.

Publication year - 1971

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19710540513

Subject(s) - chemistry , thyrotropin releasing hormone , histidine , alanine , arginine , residue (chemistry) , bioassay , stereochemistry , biological activity , lysine , hormone , amino acid , endocrinology , medicine , biochemistry , in vitro , biology , genetics

The syntheses and biological activities of 4 analogues of the thyrotropin‐releasing hormone (TRH) are described. In these analogues the histidine residue has been replaced by L ‐lysine, L ‐α,γ‐diaminobutyric acid, β‐(3‐pyrazolyl)‐ L ‐alanine, and L‐arginine. All analogues exhibited the characteristic biological responses of TRH. For the β‐(3‐pyrazolyl)‐ L ‐alanine analogue as well as for TRH the bioassays suggest an induction of a strong and rapid resynthesis of thyrotropin (TSH) in higher (μg) concentrations.

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