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Synthese von lipophil substituierten ACTH‐Peptiden
Author(s) -
Brugger M.
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540505
Subject(s) - chemistry , stereochemistry , peptide , amide , alkyl , proline , amino acid , organic chemistry , biochemistry
With a view to rendering ACTH peptides absorbable by the oral route, a series of such peptides with increased lipophilic character was built up. This paper describes the synthesis of eleven derivatives of the ACTH peptide [ D ‐Ser 1 , Lys 17,18 ]‐β‐corticotrophin‐(1–19)‐nonadeca‐peptide, containing lipophilic alkyl substituents of different kinds and sizes, bound to the carboxyl of terminal proline either by ester or amide linkage. The unsubstituted peptide [ D ‐Ser 1 , Lys 17,18 ]‐β‐corticotrophin‐(1–19)‐nonadecapeptide, and its C‐terminal amide were also synthesized.