Synthese von lipophil substituierten ACTH‐Peptiden

With a view to rendering ACTH peptides absorbable by the oral route, a series of such peptides with increased lipophilic character was built up. This paper describes the synthesis of eleven derivatives of the ACTH peptide [ D ‐Ser 1 , Lys 17,18 ]‐β‐corticotrophin‐(1–19)‐nonadeca‐peptide, containing lipophilic alkyl substituents of different kinds and sizes, bound to the carboxyl of terminal proline either by ester or amide linkage. The unsubstituted peptide [ D ‐Ser 1 , Lys 17,18 ]‐β‐corticotrophin‐(1–19)‐nonadecapeptide, and its C‐terminal amide were also synthesized.