Premium
Crystal Structure of the Antibiotic Monensin Similarities and Differences between Free Acid and Metal Complex
Author(s) -
Lutz W. K.,
Winkler F. K.,
Dunitz J. D.
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540419
Subject(s) - monensin , chemistry , orthorhombic crystal system , hydrogen bond , crystallography , crystal structure , metal , group (periodic table) , salt (chemistry) , stereochemistry , inorganic chemistry , molecule , organic chemistry
The structure of monensin, C 36 H 62 O 11 , has been determined by X ‐ray analysis of its crystalline monohydrate (orthorhombic, a = 15.15, b = 23.61, c = 10.65 Å, Z = 4, space group P 2 1 2 1 2 1 ). Phases were assigned by direct methods, making use of the ‘tangent formula’. Although the conformation of the free acid resembles that of the silver salt in being cyclic, there are differences in the hydrogen bonding pattern. These features are discussed in relation to the complexation of metal ions by monensin.