Premium
Recherches en vue de la synthèse de barbituriques organostannylés, II
Author(s) -
Maire Jean Claude,
Van Rietschoten Jurphaas
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540412
Subject(s) - chemistry , diethyl malonate , malonate , medicinal chemistry , yield (engineering) , double bond , sodium hydride , urea , hydride , organic chemistry , catalysis , hydrogen , materials science , metallurgy
Abstract (a) The synthesis of 2,4,6‐trioxo‐1, 3‐di‐tributylstannyl‐hexahydropyrimidine is described. (b) Trimethyltin hydride is found to add in a photochemical reaction to the terminal double bond of diethyl allyl malonate and allyl methyl malonate, giving respectively diethyl‐(3‐trimethylstannylpropyl)‐ ( 1 ) and diethyl‐(3‐trimethylstannylpropyl) ( 2 ) methyl‐malonates. Treated with urea under the usual conditions, ( 1 ) and ( 2 ) yield organostannyl barbituric acids.