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Synthese eines neuen Derivats der Insulinsequenz B1–8 mit verbesserter Löslichkeit
Author(s) -
Bosshard H. R.
Publication year - 1971
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19710540403
Subject(s) - chemistry , hydrazide , glycine , stereochemistry , sequence (biology) , solubility , amino acid , organic chemistry , biochemistry
The synthesis of the protected octapeptide N‐ t ‐butoxycarbonyl‐phenylalanyl‐valylasparaginyl‐glutaminyl‐N im ‐tritylhistidyl‐leucyl‐S‐benzhydrylcysteinyl‐glycine‐hydrazideL , corresponding to the amino‐terminal sequence of the insulin B‐chain, is described. Up to the protected octapeptide all intermediates have greatly improved solubility properties in neutral organic solvents in comparison with other synthetic derivatives of the same sequence.