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Über das Hydrolysegleichgewicht von Phenylbutazon (Butazolidin®)
Author(s) -
Schmid R. W.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530837
Subject(s) - chemistry , phenylbutazone , aqueous solution , solvent , reaction rate , aqueous medium , computational chemistry , medicinal chemistry , organic chemistry , catalysis , medicine , pharmacology
Abstract Phenylbutazone (I) forms in aqueous and partially aqueous solution butylmalonic acid mono (N, N′‐diphenylhydrazide) (II) by a reversible reaction. The reaction rate and the position of equilibrium depend on the solvent but practically not on the pH. The temperature dependence is given for several media. Substituents affect the reaction rate when they are in 4‐position but not in 4′‐ or 4″‐position. Based on the kinetic data, a reaction mechanism is proposed. Methods for the analysis of I in mixtures with II are presented. The preparation of II is described.