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Die Struktur des Antibioticums Roridin E. Verrucarine und Roridine, 21. Mitteilung [1]
Author(s) -
Traxler P.,
Zürcher W.,
Tamm Ch.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530818
Subject(s) - chemistry , stereochemistry , derivative (finance) , economics , financial economics
Structure 1 has been established for roridin E (C 29 H 38 O 8 ), an antibiotic isolated from cultures of Myrothecium species. Base catalysed hydrolysis of 1 gave the known sesquiterpene alcohol verrucarol ( 4 ; C 15 H 22 O 4 ) and 2′‐anhydrororidinic acid ( 6 ; C 14 H 20 O 6 ), a new dicarboxylic acid. The structure of 6 was determined by spectral analysis of its dimethyl ester 7 , dimethyl hexahydro‐2′‐anhydrororidinate ( 9 ), the acetyl derivative 10 , and the oxidation product 11 .