Premium
Synthèse d'analogues partiellement saturés des neuroleptiques tricycliques clothiapine et octoclothépine. 3 me Communication sur les antidépresseurs et les neuroleptiques tricycliques [1]
Author(s) -
Dostert P.,
Kyburz E.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530729
Subject(s) - chemistry , diastereomer , ring (chemistry) , stereochemistry , organic chemistry
Abstract In order to check if the pharmacological activity is retained when the non‐substituted aromatic ring of the neuroleptics clothiapine (I) and octoclothepine (II) is saturated, we have prepared the trans ‐hexahydro‐clothiapine XXIV and one of the two possible diastereoisomers each of cis and trans hexahydro‐octoclothepine XL and XLI.