Premium
Alkalikationen‐Spezifität und Träger‐Eigenschaften der Antibiotica Nigericin und Monensin
Author(s) -
Lutz W. K.,
Wipf H.K.,
Simon W.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530723
Subject(s) - nigericin , monensin , chemistry , membrane , ionophore , potassium , sodium , inorganic chemistry , medicinal chemistry , organic chemistry , biochemistry
It is shown by means of IR. spectroscopic methods that nigericin and monensin have a cyclic conformation similar to that of their silver salts. Complex formation constants with sodium and potassium ions follow the selectivity order determined by EMF. measurements on liquid membranes: nigericin: K + > Rb + > Na + > Cs + > Li + ; monensin: Na + > K + > Li + > Rb + > Cs + . Transport experiments show that nigericin and monensin facilitate the diffusion of potassiumions across model membranes, although in electrolytic transport experiments the permeability is not affected.