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Modelle für Kopplungsmechanismus und Träger‐induzierten Alkaliionentransport in Mitochondrienmembranen
Author(s) -
Wipf H.K.,
Simon W.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530722
Subject(s) - chemistry , decoupling (probability) , valinomycin , oxidative phosphorylation , alkali metal , biophysics , stereochemistry , ion , biochemistry , organic chemistry , control engineering , engineering , biology
Energetic coupling of oxidative phosphorylation in mitochondria is discussed in the light of recent findings concerning mediation of alkali cation transport by antibiotics: Decoupling by cation‐specific antibiotics of the valinomycin group, as well as by classical decoupling agents ( e.g. 2,4‐dinitrophenol), can easily be interpreted on the basis of their known molecular properties if Mitchell's chemi‐osmotic theory is accepted. «Ion pump» mechanisms, as proposed by several authors, require additional assumptions that do not seem justified.