Premium
Mechanismus und Selektivität des Alkali‐Ionentransportes in Modell‐Membranen in Gegenwart des Antibioticums Valinomycin
Author(s) -
Wipf H.K.,
Olivier A.,
Simon W.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530706
Subject(s) - valinomycin , chemistry , membrane , potassium , inorganic chemistry , alkali metal , ion , organic chemistry , biochemistry
Selective transport of potassium ions through synthetic membranes impregnated with valinomycin in octane‐2‐ol in the presence of equal amounts of K + and Na + or Li + ions is induced on application of a potential difference across these membranes. By using 14 C‐labelled valinomycin it is shown that transport of potassium ions is accompanied by an equivalent transport of valinomycin within the membrane, consistent with the formation of a 1 : 1 complex of K + with valinomycin. The exchange of ligands is shown to occur during the transport process so that a carrier‐relay mechanism, as proposed earlier for macrotetrolide‐mediated potassium transport, accounts for all experimental results on the bulk membranes studied.